Application Imdur 30 mg:
Imdur 30 mg CHD (long treatment), angina and vasospastic (prevention of attacks), angina in the myocardial infarction, congestive heart failure (combined therapy), pulmonary hypertension.
Contra Imdur 30 mg:
Hypersensitivity, acute myocardial infarction with reduced left ventricular filling pressure, acute left ventricular failure, cardiogenic shock, vascular collapse, severe hypotension (SBP less than 90 mm Hg), hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade, intracranial hemorrhage, brain hypertension, severe anemia, glaucoma, pregnancy (I trimester) and breastfeeding.
Restrictions apply Imdur 30 mg:
Acute myocardial infarction, unstable angina, acute coronary syndrome, children’s age (safety and efficacy in children has not been studied).
Application Imdur during pregnancy and breastfeeding Imdur 30 mg:
The use of isosorbide mononitrate medication during pregnancy is possible only in cases where the expected benefit exceeds the possible negative effects on the fetus. At the time of treatment is recommended to stop breastfeeding.
Side effects Imdur 30 mg:
Since the nervous system and sensory organs: “nitrate” headache, weakness, agitation.
With the cardiovascular system and blood (hematopoiesis, hemostasis): transient reddening of the skin, hypotension, including Orthostatic (accompanied by reflex tachycardia, confusion, dizziness, paleness, etc.), with severe arterial hypotension may increase the symptoms of angina (paradoxical effect of nitrates) and / or severe paradoxical bradycardia, collapse, syncope, methemoglobinemia (long-term treatment).
From the digestive tract: dry mouth, nausea, and vomiting.
Allergic reactions Imdur 30 mg:
burning and itching, exfoliative dermatitis.
Other: sweating, transient hypoxemia, increased levels of catecholamines and vanillin-succinic acid in the urine.
Interaction Imdur 30 mg:
Strengthens the antihypertensive effect of vasodilators, beta-blockers, calcium antagonists, narcotic analgesics, antipsychotics, tricyclic antidepressants, sildenafil citrate and alcohol. With simultaneous administration of alcohol increases reduce the ability for rapid mental and motor responses. Barbiturates accelerate the biotransformation and reduce the concentration of isosorbide mononitrate in the blood. Weakens the therapeutic effect of norepinephrine. When concomitantly with NSAIDs, possibly weakening their actions.
Overdose Imdur 30 mg:
Symptoms: orthostatic hypotension, a sense of compression of the head, throbbing headache, severe sweating, skin cold and covered with sticky sweat, or hyperemic, palpitations, bradycardia, conduction disturbances (blockade), shortness of breath, Kussmaul breathing, bloody diarrhea, vomiting, dizziness, confusion, syncope, coma, fever, paralysis, visual disturbances.
Treatment: gastric lavage, giving the horizontal position with legs elevated, iv drip infusion, monitoring the level of methemoglobin in the blood when it is increasing – the appointment of ascorbic acid at a dose of 1 g orally, methylthioninium chloride (methylene blue) w / up to 50 ml of 1% solution, toluidine blue – 2-4 mg / kg body weight / in quickly, if necessary – again in a dose of 2 mg / kg at intervals of 1 h, oxygen therapy, hemodialysis, exchange transfusion.
Dosing and Administration Imdur 30 mg:
inside, not liquid and not razlamyvaya, squeezed a small amount of liquid. The dose is determined individually. Initial dose – 10-20 mg 2 times daily or 40-50 mg once daily after breakfast (for a prolonged forms). If necessary, 3-5-day treatment dose can be increased to 20-40 mg 2 times per day or 80-100 mg once (for long-acting forms). When you receive 2 times a day recommended to “asymmetric” scheme: first reception immediately after awakening, the second – after 7 pm
Precautions Imdur 30 mg:
In cases of hypotension used only under medical supervision. In the appointment of the drug should be particularly careful monitoring of patients with aortic and / or mitral stenosis. Should not be used for relief of angina attack. It is not recommended to drive vehicles and doing other potentially hazardous activities during treatment (possibly reducing the concentration of attention and the ability to rapid mental and motor responses). With long-term continuous administration of high doses may develop tolerance. Abolition of the drug should be gradual to avoid the development of withdrawal syndrome.
